Much remains to be clarified experimentally, but the hypothesis offers a biologically plausible and clinically suggestive framework for linking endogenous morphine, dopamine, GLP-1 therapeutics, and mitochondrial regulation in one evolutionary narrative
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Not only is the maturation ability of oocytes from EMS patients reduced, but also cortical granule loss, spindle fragmentation, and zona pellucis sclerosis may develop in immature oocytes following maturation and culture to meiosis II in vitro , which may impede with sperm penetration (28)
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